LAB MEMBERS

Contact Information   e-mail dawg@uchicago.edu

GLYN DAWSON PhD  Principal Investigator

Jingdong Qin Research Associate Professor

Jingdong obtained his Ph.D in China and worked both in Biotech and cancer research in Jerusalem before joining my Laboratory in 2004.  He worked on the role of bio-active sphingolipids especially ceramide/S1P and their metabolically  related enzymes such as sphingomyelinases and sphingosine kinases in cancers and neurodegenerative disorders. By using a variety of agonists and antagonists of enzymes and employing an advanced quantum dots system, he is developing effective treatments for cancers and neurodegeneration diseases. He has also developed a pre-adipocyte cell model and used it to study gene markers of different types of fat cells with the objective of developing new therapies  for obesity/diabetes.

John Kilkus  Lab Manager/Research Specialist 2 John joined the Lab 20 years ago and runs the lipid metabolic experiments, using both radioactive and fluorescent probes, as well as being the Lab manager.  His only weakness is a devotion to the Cubs.

Sylvia Dawson  Research Specialist 1.

Sylvia joined the Lab as a part-time research technician 25 years ago after working on a project to define autism as an autoimmune disease involving the serotonin 5HT1A receptor.  She concentrates mostly on cell culture, lysosomal hydrolase assays and computer graphics.

Ted Getz Undergraduate Biochemistry Student

Ted Getz also joined the Lab in April 2013 and graduated with honors in Chemistry and Biochemistry. He is from St. Joseph MI and worked in the Lab on developing a Quantum Dot mediated SiRNA delivery system. We are currently preparing his work for publication, based on his honors thesis. /page/abstracts-recent-papers

Connor Lynch Undergraduate Biochemistry Student

Connor Lynch

Connor Lynch is a 4th year BioChemistry and English major who joined the lab in April 2014. He is working on in-ovo chick embryo and an in-vitro mouse models to assess delivery specificity for QD-ligand conjugates, with particular focus on visible light imaging of target cells in intact tissue.

Sho Yano MD12 PhD12

Sho Yano

Sho Yano has rejoined the Lab after completing his residency in Pediatric Neurology.  He is exploring the use of QDs coated with peptide to deliver silencing RNA to cells.

Lita M Araysi   Student

Lita M Araysi

Lita Araysi is using RNAi technology to supress the synthesis of a key protein in drug resistance and sphingolipid synthesis: Ceramide glucosyltranferase.  The key to success is the discovery that negatively charged RNA will bind to positively charged regions on the Quantum dots.

Surabhi Hoover

Surabhi Hoover

Surabhi Hoover has completed 2 years of her neuroscience major and is studying how we can deliver and image 630nm fluorescent Quantum Dots following attachment of a therapeutic agent. We have established the lack of toxicity of the Quantum Dots in cultured cells, embryonic development and at least 100 days in mice.  Surabhi will now start to load biological cargo such large proteins on to the Quantum Dots and attempt to reverse brain pathology in mouse brain slices which have been genetically modified to have no tripepatidyl peptidase in their lysosomes- a model for Late Infantile Batten disease.

Visiting now and then.

Fernando Testai

Fernando TestaiFernando Testai.  Fernando spent a year with us (2004) and continued research during his Neurology Fellowship.  Now an Assistant Professor at UIC he maintains links through his interest in the role of sphingolipids in hemorrhagic stroke and its outcome.